1,4-Dioxane hydrochloride → 2-((3-(Pyridin-4-ylmethyl)ureido)oxy)acetic acid

Participants

Reaction Steps

To a solution of tert-butyl 2-(3-(pyridin-4-ylmethyl)ureidooxy)acetate (Compound V-5) (42.2 mg, 0.15 mmol) in tetrahydrofuran (1 ml) was added 4N HCl/dioxane (2 ml) and the mixture was stirred at room temperature for 3 days. The reaction mixture was concentrated in vacuo to obtain the title compound (34 mg, 100%).

Provenance & Evidence