1,4-Dioxane hydrochloride → 2-(3-(4-Chlorobenzyl)ureidooxy)acetic acid

HRID 2274629Notes

Reaction equation

HRID 2274629 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][NH:7][C:8](=[O:19])[NH:9][O:10][CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])=[CH:4][CH:3]=1.Cl.O1CCOCC1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8](=[O:19])[NH:9][O:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86658800HCID 86658800, compound

Product 1

HCID 533975002-(3-(4-Chlorobenzyl)ureidooxy)acetic acidYield 100.5%

Procedure

According to the procedure described in the synthesis method of Compound VI-9, tert-butyl 2-(3-(4-chlorobenzyl)ureidooxy)acetate (Compound V-6)(47.2 mg, 0.15 mmol) was reacted with 4N HCl/dioxane (2 ml) to obtain the title compound (39 mg, 100%).

Sources & evidence

ORD record
ord-f4dc9772667a47ec8a7bf2b072c93b10
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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