2,2-Diethoxyethylamine → HCID 42609175, compound

HRID 2274638Notes

Reaction equation

[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].[N:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][C:18]=2[CH:20]=O)[CH:13]=[CH:12][CH:11]=1>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:20][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[N:10]=[CH:11][CH:12]=[CH:13]2)[CH3:2]

Participants

Reactant 2

HCID 695242,2-Diethoxyethylamine

HCID 1701038-Quinolinecarboxaldehyde

Product 1

HCID 42609175HCID 42609175, compoundYield 91.1%

Procedure

According to the procedure described in the synthesis method of Compound IX-2 with the modification that the reaction was carried out overnight, 2,2-diethoxyethanamine (2.18 ml, 15 mmol) was reacted with 8-quinolinecarboxaldehyde (1.89 g, 12 mmol) to obtain the title compound (3.0 g, 73%).

Workup

customdescribed in the synthesis method of Compound IX-2 with the modification that the reaction

Sources & evidence

ORD record: ord-4f99967af3164a16995db6e3123e727d
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09126981B2

Reaction notes

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