Isoquinoline-5-carboxaldehyde → HCID 67303773, compound

HRID 2274644Notes

Reaction equation

HRID 2274644 reaction equation
[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[C@@H:5]([NH2:7])[CH3:6])[CH3:2].[CH:11]1[C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([CH:21]=O)[C:15]=2[CH:14]=[CH:13][N:12]=1>>[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[C@@H:5]([NH:7][CH2:21][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:15]=1[CH:14]=[CH:13][N:12]=[CH:11]2)[CH3:6])[CH3:2]

Participants

3

Reactant 2

HCID 7016853Isoquinoline-5-carboxaldehydeHCID 12398111(2S)-1,1-Diethoxy-2-propanamine

Product 1

HCID 67303773HCID 67303773, compoundYield 95%

Procedure

According to the procedure described in the synthesis method of Compound IX-6, (S)-1,1-diethoxypropan-2-amine (Compound XVIII-1) (883 mg, 6.0 mmol) was reacted with isoquinoline-5-carbaldehyde (802 mg, 5.1 mmol) to obtain the title compound (1.37 g, 95%).

Sources & evidence

ORD record
ord-f3a562f7b364406cad80c471d177ae96
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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