HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chlorothieno[3,2-b]pyridine-3-carbaldehyde → (S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chlorothieno[3,2-b]pyridine-3-carbaldehyde | HCID 1476264 | — |
| Reactant | (2S)-1,1-Diethoxy-2-propanamine | HCID 12398111 | — |
| Product | (S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine | HCID 86652569 | 30.3% |
Reaction Steps
According to the procedure described in the synthesis method of Compound IX-6, (S)-1,1-diethoxypropan-2-amine (Compound XVIII-1) (1.98 g, 13.4 mmol) was reacted with 5-chlorothieno[3,2-b]pyridine-3-carbaldehyde (Compound XIX-1) (1.98 g, 10 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=98:2 to 95:5) to obtain the title compound (996 mg, 30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126981B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-dd963f99803f4e94aa3379ce37002487 |
| Source note | uspto-grants-2015_09 |