HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridinemethanamine → N-(2,2-Diethoxyethyl)pyridine-2-methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridinemethanamine | HCID 19509 | — |
| Reactant | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| Product | N-(2,2-Diethoxyethyl)pyridine-2-methylamine | HCID 81407 | 65.9% |
Reaction Steps
According to the procedure described in the synthesis method of Compound IX-1, 2-bromo-1,1-diethoxyethane (34.6 ml, 230 mmol) was reacted with 2-picolylamine (50 g, 460 mmol) and the obtained residue was purified by silica gel column chromatography (eluent: ethyl acetate:ethanol=10:1) to obtain the title compound (34.0 g, 65%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126981B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-dd86ad9eb50e4b2cac1cc1860c87a625 |
| Source note | uspto-grants-2015_09 |