2,2-Diethoxyethylamine → HCID 66978200, compound

HRID 2274651Notes

Reaction equation

HRID 2274651 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].[F:10][C:11]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:12]=1[CH:13]=O>>[F:10][C:11]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:12]=1[CH2:13][NH:6][CH2:5][CH:4]([O:7][CH2:8][CH3:9])[O:3][CH2:1][CH3:2]

Participants

3

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 737702,4-Difluorobenzaldehyde

Product 1

HCID 66978200HCID 66978200, compoundYield 37.1%

Procedure

According to the procedure described in the synthesis method of Compound IX-2, 2,2-diethoxyethanamine (75.6 ml, 520 mmol) was reacted with 2,4-difluorobenzaldehyde (75 g, 520 mmol) and the obtained residue was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=5:1 and 3:1) to obtain the title compound (50.0 g, 36%).

Workup

  1. customthe obtained residue was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=5:1 and 3:1)

Sources & evidence

ORD record
ord-2091007525b24f9cb9296bac1d716bce
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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