1-Bromo-3-methylbutane → HCID 78912157, compound

HRID 2274652Notes

Reaction equation

HRID 2274652 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].[CH2:10](Br)[CH2:11][CH:12]([CH3:14])[CH3:13]>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:10][CH2:11][CH:12]([CH3:14])[CH3:13])[CH3:2]

Participants

3

Reactant 2

HCID 78911-Bromo-3-methylbutaneHCID 695242,2-Diethoxyethylamine

Product 1

HCID 78912157HCID 78912157, compoundYield 77.2%

Procedure

According to the procedure described in the synthesis method of Compound IX-5 with the modification that the reaction was carried out overnight, 2,2-diethoxyethanamine (2.91 ml, 20 mmol) was reacted with isoamylbromide (1.26 ml, 10 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: n-hexane:ethyl acetate=90:10 to 80:20) to obtain the title compound (1.57 g, 77%).

Workup

  1. customdescribed in the synthesis method of Compound IX-5 with the modification that the reaction
  2. customthe obtained residue was purified by Büch silica gel column chromatography (eluent: n-hexane:ethyl acetate=90:10 to 80:20)

Sources & evidence

ORD record
ord-dcac930b7c02483e850a0d5dd1d1baca
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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