Phenethyl bromide → N-(2-Phenylethyl)aminoacetaldehyde diethyl acetal

HRID 2274653Notes

Reaction equation

HRID 2274653 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].Br[CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:2]

Participants

3

Reactant 2

HCID 7666Phenethyl bromideHCID 695242,2-Diethoxyethylamine

Product 1

HCID 523116N-(2-Phenylethyl)aminoacetaldehyde diethyl acetalYield 94%

Procedure

According to the procedure described in the synthesis method of Compound IX-1, 2,2-diethoxyethanamine (5.82 ml, 40 mmol) was reacted with (2-bromoethyl)benzene (2.70 ml, 20 mmol) and the obtained residue was purified by Büch silica gel column chromatography (chloroform only) to obtain the title compound (4.45 g, 94%).

Workup

  1. customthe obtained residue was purified by Büch silica gel column chromatography (chloroform only)

Sources & evidence

ORD record
ord-4a6e66be2fbc4b9782da961247b0030a
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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