(3-Bromopropyl)benzene → HCID 66978315, compound

HRID 2274654Notes

Reaction equation

HRID 2274654 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].[C:10]1([CH2:16][CH2:17][CH2:18]Br)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:18][CH2:17][CH2:16][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 12503(3-Bromopropyl)benzeneHCID 695242,2-Diethoxyethylamine

Product 1

HCID 66978315HCID 66978315, compoundYield 27.3%

Procedure

According to the procedure described in the synthesis method of Compound IX-1, 2,2-diethoxyethanamine (5.82 ml, 40 mmol) was reacted with 3-phenylpropyl bromide (3.02 ml, 20 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform only) to obtain the title compound (1.37 g, 27%).

Workup

  1. customthe obtained residue was purified by Büch silica gel column chromatography (eluent

Sources & evidence

ORD record
ord-eb5fc2f8a85f496a90f186172bc77aaa
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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