2,2-Diethoxyethylamine → HCID 66978174, compound

HRID 2274655Notes

Reaction equation

HRID 2274655 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].[C:10]1([CH:16]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:17][CH2:18]Br)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:18][CH2:17][CH:16]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH3:2]

Participants

3

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 883331,1'-(3-Bromopropylidene)bisbenzene

Product 1

HCID 66978174HCID 66978174, compoundYield 61%

Procedure

According to the procedure described in the synthesis method of Compound IX-1, 2,2-diethoxyethanamine (5.82 ml, 40 mmol) was reacted with 3,3-diphenylpropyl bromide (5.50 g, 20 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: n-hexane:ethyl acetate=90:10 to 80:20) to obtain the title compound (3.98 g, 61%).

Workup

  1. customthe obtained residue was purified by Büch silica gel column chromatography (eluent: n-hexane:ethyl acetate=90:10 to 80:20)

Sources & evidence

ORD record
ord-d4c80d8014fd4b7ba91c27af68f4eaac
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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