2,2-Diethoxyethylamine → HCID 67303713, compound

HRID 2274658Notes

Reaction equation

HRID 2274658 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].Br[CH2:11][CH2:12][O:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][O:15]1>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:11][CH2:12][O:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][O:15]1)[CH3:2]

Participants

3

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyran

Product 1

HCID 67303713HCID 67303713, compoundYield 30.4%

Procedure

According to the procedure described in the synthesis method of Compound IX-5 with the modification that the reaction was carried out overnight, 2,2-diethoxyethanamine (5.82 ml, 40 mmol) was reacted with 2-(2-bromoethoxy)tetrahydro-2H-pyran (3.03 ml, 20 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=100:0 to 98:2) to obtain the title compound (1.59 g, 30%).

Workup

  1. customdescribed in the synthesis method of Compound IX-5 with the modification that the reaction
  2. customthe obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=100:0 to 98:2)

Sources & evidence

ORD record
ord-f7f10b937cd74e3b85d017ed4bd423ab
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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