2,2-Diethoxyethylamine → HCID 377626, compound

HRID 2274660Notes

Reaction equation

HRID 2274660 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].Br[CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14]>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])[CH3:2]

Participants

3

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 76934Methyl 3-bromopropanoate

Product 1

HCID 377626HCID 377626, compoundYield 27%

Procedure

According to the procedure described in the synthesis method of Compound IX-5 with the modification that the reaction was carried out overnight, 2,2-diethoxyethanamine (8.72 ml, 60 mmol) was reacted with methyl 3-bromopropionate (3.27 ml, 30 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=100:0 to 98:2) to obtain the title compound (1.75 g, 27%).

Workup

  1. customdescribed in the synthesis method of Compound IX-5 with the modification that the reaction
  2. customthe obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=100:0 to 98:2)

Sources & evidence

ORD record
ord-ee012e1bfcec4fb0b88958e17b59eb3d
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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