Fmoc-L-Tyr(tBu)-OH → HCID 67447642, compound

Participants

Reaction Steps

According to the procedure described in the synthesis method of Compound III-1, 2,2-diethoxy-N-(quinolin-8-ylmethyl)ethanamine (Compound IX-3) (1.37 g, 5 mmol) was coupled with (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoic acid (2.76 g, 6 mmol) and the obtained residue was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=7:3 to 5:5) to obtain the title compound (0.62 g, 17%).

Provenance & Evidence