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HRID2274664

反应详情

EQUATION

反应方程式

HRID 2274664 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)Oc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
HCID10895791

Fmoc-L-Tyr(tBu)-OH

C28H29NO5

结构：CCOC(OCC)[C@H](C)NCc1cccc2ccccc12
HCID67075196

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(OCC)[C@H](C)N(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
HCID86698526

(9H-fluoren-9-yl)methyl (S)-3-(4-tert-butoxyphenyl)-1-(((S)-1,1-diethoxypropan-2-yl)(naphthalen-1-ylmethyl)amino)-1-oxopropan-2-ylcarbamate

C46H52N2O6

收率 79.1%

PROCEDURE

实验过程

According to the procedure described in the synthesis method of Compound III-5, (S)-1,1-diethoxy-N-(naphthalen-1-ylmethyl)propan-2-amine (Compound IX-6)(686 mg, 2.4 mmol) was coupled with (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoic acid (1.15 g, 2.51 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: n-hexane:ethyl acetate=7:3) to obtain the title compound (1.384 g, 79%).

WORKUP

后处理

  1. customthe obtained residue was purified by Büch silica gel column chromatography (eluent: n-hexane:ethyl acetate=7:3)