HuagongsheHuagongshe Chemistry Print Report · For research reference only
ethyl 3-(morpholin-4-ylsulfonyl)-7-nitro-1H-indole-2-carboxylate → 3-(morpholin-4-ylsulfonyl)-7-nitro-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ethyl 3-(morpholin-4-ylsulfonyl)-7-nitro-1H-indole-2-carboxylate | HCID 57445031 | — |
| Reactant | ethyl 5-chloro-3-(morpholin-4-ylsulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 68444586 | — |
| Reactant | ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86592455 | — |
| Reactant | ethyl 3-(chlorosulfonyl)-7-nitro-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86592456 | — |
| Product | 3-(morpholin-4-ylsulfonyl)-7-nitro-1H-indole-2-carboxamide | HCID 57445030 | — |
Reaction Steps
Following the procedures described in Steps B and C of Example 2 and E of Example 1, replacing in Step B of Example 2 ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 3-(chlorosulfonyl)-7-nitro-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and replacing in Step E of Example 1 ethyl 5-chloro-3-(morpholin-4-ylsulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 3-(morpholin-4-ylsulfonyl)-7-nitro-1H-indole-2-carboxylate, the title compound was obtained. HRMS (ES) exact mass calculated for C13H15N4O6S (M+H+): 355.0707. Found 355.0713.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560546B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-b09fb84fe2e449f0a75020e325b77aa0 |
| Source note | uspto-grants-2009_07 |