HCID 24773279, compound → HCID 67445858, compound

HRID 2274699Notes

Reaction equation

HRID 2274699 reaction equation
[CH2:1]([NH:8][C:9]([NH:11][N:12]([C:14]([CH3:19])([CH3:18])[C:15]([OH:17])=O)[CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:20][C@@H:21]([CH2:44][C:45]1[CH:50]=[CH:49][C:48]([O:51][C:52]([CH3:55])([CH3:54])[CH3:53])=[CH:47][CH:46]=1)[C:22]([N:24]([CH2:36][CH:37]([O:41][CH2:42][CH3:43])[O:38][CH2:39][CH3:40])[CH2:25][C:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28][CH:27]=1)=[O:23]>>[CH2:1]([NH:8][C:9]([NH:11][N:12]([C:14]([CH3:19])([CH3:18])[C:15]([NH:20][C@@H:21]([CH2:44][C:45]1[CH:50]=[CH:49][C:48]([O:51][C:52]([CH3:54])([CH3:53])[CH3:55])=[CH:47][CH:46]=1)[C:22]([N:24]([CH2:36][CH:37]([O:41][CH2:42][CH3:43])[O:38][CH2:39][CH3:40])[CH2:25][C:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28][CH:27]=1)=[O:23])=[O:17])[CH3:13])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 24773279HCID 24773279, compoundHCID 67303614HCID 67303614, compound

Product 1

HCID 67445858HCID 67445858, compoundYield 58%

Procedure

According to the procedure described in the synthesis method of Compound II-1, 2-(2-(benzylcarbamoyl)-1-methylhydrazinyl)-2-methylpropanoic acid (Compound VI-5) (441 mg, 1.67 mmol) was coupled with (S)-2-amino-3-(4-tert-butoxyphenyl)-N-(2,2-diethoxyethyl)-N-(naphthalen-1-ylmethyl)propanamide (Compound IV-2) (544.6 mg, 1.11 mmol) and the obtained residue was purified by silica gel column chromatography (eluent: chloroform:methanol=98:2) to obtain the title compound (476 mg, 58%).

Workup

  1. customthe obtained residue was purified by silica gel column chromatography (eluent: chloroform:methanol=98:2)

Sources & evidence

ORD record
ord-25943baadcf04bc9abe8cdb761bd78a4
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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