HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 3-(azetidin-1-ylsulfonyl)-5-chloro-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Azetidine | HCID 10422 | — |
| Reactant | ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 22401482 | — |
| Reactant | ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86592455 | — |
| Product | 3-(azetidin-1-ylsulfonyl)-5-chloro-1H-indole-2-carboxamide | HCID 10064201 | — |
Reaction Steps
The titled compound was prepared using the procedures described in Steps B and C of Example 2, followed by the procedure described in Step E of Example 1, replacing in Step B of Example 2 ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and morpholine with azetidine. Proton NMR for the product was consistent with the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560546B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-5512a0cda45f41debcf7343aeb72c196 |
| Source note | uspto-grants-2009_07 |