Phenethyl bromide → HCID 178420289, compound

HRID 2274719Notes

Reaction equation

HRID 2274719 reaction equation
[NH:1]1[C:5]2[CH:6]=[C:7]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[C:16]1([CH2:22][CH2:23]Br)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CCO>[CH2:23]([S:15][C:13]1[O:14][C:10]([C:7]2[CH:8]=[CH:9][C:4]3[NH:3][CH:2]=[N:1][C:5]=3[CH:6]=2)=[N:11][N:12]=1)[CH2:22][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 7666Phenethyl bromideHCID 178527937HCID 178527937, compound

Product 1

HCID 178420289HCID 178420289, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 (0.33 g, 1.5 mmol), TEA (0.209 mL, 1.5 mmol), phenylethylbromide (0.206 mL, 1.5 mmol) were dissolved in 10 mL of EtOH and kept under reflux overnight. The solvent was removed and the remaining oil was purified by flash-chromatography on silica gel, applying a CHCl3/MeOH gradient.

Workup

  1. temperatureunder reflux overnight
  2. customThe solvent was removed
  3. customthe remaining oil was purified by flash-chromatography on silica gel

Sources & evidence

ORD record
ord-0673833cd8f540efa7edac30d9ea4311
Source dataset
uspto-grants-2015_09
Patent number
US09126987B2

Reaction notes

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