Methyl iodide → HCID 178503610, compound

HRID 2274722Notes

Reaction equation

HRID 2274722 reaction equation
[NH:1]1[C:5]2[CH:6]=[C:7]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:16]I>CCO>[CH3:16][S:15][C:13]1[O:14][C:10]([C:7]2[CH:8]=[CH:9][C:4]3[NH:3][CH:2]=[N:1][C:5]=3[CH:6]=2)=[N:11][N:12]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178527937HCID 178527937, compound

Product 1

HCID 178503610HCID 178503610, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 (0.33 g, 1.5 mmol), TEA (0.209 mL, 1.5 mmol) and methyliodide (0.093 mL, 1.5 mmol) were dissolved in 10 mL of EtOH and kept under reflux overnight. The solvent was removed and the remaining oil was purified by flash-chromatography on silica gel, applying a CHCl3/MeOH gradient.

Workup

  1. temperatureunder reflux overnight
  2. customThe solvent was removed
  3. customthe remaining oil was purified by flash-chromatography on silica gel

Sources & evidence

ORD record
ord-4b22db819b3342948c9235e50446de12
Source dataset
uspto-grants-2015_09
Patent number
US09126987B2

Reaction notes

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