3,4,5-Trifluorobenzyl bromide → HCID 178505903, compound

HRID 2274729Notes

Reaction equation

HRID 2274729 reaction equation
[NH:1]1[C:5]2[CH:6]=[C:7]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[C:23]([F:26])[C:24]=1[F:25])[CH2:20]Br>CCO>[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[C:23]([F:26])[C:24]=1[F:25])[CH2:20][S:15][C:13]1[O:14][C:10]([C:7]2[CH:8]=[CH:9][C:4]3[NH:3][CH:2]=[N:1][C:5]=3[CH:6]=2)=[N:11][N:12]=1

Participants

4

Reactant 2

HCID 27770623,4,5-Trifluorobenzyl bromideHCID 178527937HCID 178527937, compound

Product 1

HCID 178505903HCID 178505903, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 (0.33 g, 1.5 mmol), TEA (0.209 mL, 1.5 mmol) and 3,4,5-trifluorobenzylbromide (0.20 mL, 1.5 mmol) were dissolved in 10 mL of EtOH and kept under reflux overnight. The solvent was removed and the remaining oil was purified by flash-chromatography on silica gel, applying a CHCl3/MeOH gradient.

Workup

  1. temperatureunder reflux overnight
  2. customThe solvent was removed
  3. customthe remaining oil was purified by flash-chromatography on silica gel

Sources & evidence

ORD record
ord-025a6e1a62974ae6b970907d1f44769a
Source dataset
uspto-grants-2015_09
Patent number
US09126987B2

Reaction notes

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