HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-Hydroxy-3-methoxy-5-nitrobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Vanillic Acid | HCID 8468 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Hydroxy-3-methoxy-5-nitrobenzoic acid | HCID 15527939 | — |
Reaction Steps
A reactor was charged with 525 kg of glacial acetic acid and 50 kg vanillic acid. The mixture was heated with warm water gradually to 50° C. in around 75 minutes. Temperature was set to 16° C. Nitric acid, 31.4 kg was then added gradually over a period of 3 hrs. When the administration was complete the mixture was allowed to stir for additional 3.5-4.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126988B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-508357ccb6cb4bd7b7e78ebceb42009a |
| Source note | uspto-grants-2015_09 |