HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 4-Hydroxy-3-methoxy-5-nitrobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Vanillic Acid | HCID 8468 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Hydroxy-3-methoxy-5-nitrobenzoic acid | HCID 15527939 | 40% |
Reaction Steps
The process of Example 1a was scaled up to employ vanillic acid (375 g) in acetic acid (3940 g) to which was added nitric acid (65%, 245 g) at 12° C. over 3 hours followed by stirring for one hour. The overall yield was 40% of a 99.9% pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126988B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-b1952745399d466ca3a3d2d2fc814c7b |
| Source note | uspto-grants-2015_09 |