Hydrogen Bromide → HCID 178419571, compound

Participants

Reaction Steps

To a stirred suspension of N-{[(5S)-3-(2-fluoro-4′-{[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide (56.7 mg, 0.129 mmol) in ethanol (1.0 mL) was added 1.0 M hydrogen bromide in ethanol containing 8.77% water (0.39 mL, 0.39 mmol), and the resulting mixture was stirred at room temperature for 60 min. The mixture was then heated to 65° C., stirred for 60 min, cooled to room temperature and stirred for an additional 2 h. The solid was filtered and dried under reduced pressure at 50° C. to afford the title compound (64.5 mg, 94.5%) as a crystalline solid which was characterized by XRPD. FIG. 2 shows a characteristic X-ray powder diffraction (XRPD) pattern of crystalline N-{[(5S)-3-(2-fluoro-4′-{[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide monohydrobromide. Characteristic peaks, expressed in degrees 2θ, are listed in Table 2.

Provenance & Evidence