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HRID 2274764作成日：2026年10月26日

2-(4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)pyridine → 6-fluoro-1-(phenylsulfonyl)-3-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)-1H-indole

https://huagongshe.com/reaction/2274764

反応式

関与物質

役割名称HCID仕込み量
反応物2-(4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)pyridineHCID 66521245—
反応物6-fluoro-1-(phenylsulfonyl)-3-(1-(pyridin-4-yl)-1H-pyrazol-4-yl)-1H-indoleHCID 118060211—
生成物6-fluoro-1-(phenylsulfonyl)-3-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)-1H-indoleHCID 11806061962%

反応手順

Following the general method as outlined in Intermediate 10, starting from 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)pyridine (Intermediate 14; 485 mg; 1.80 mmol), 234 mg (62%) of the title compound was obtained as a yellow solid after purification by a silica gel chromatography (petroleum ether/EtOAc=1/1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09126984B2
出典データセットuspto-grants-2015_09
ORD IDord-1f856f88510543bc8e30783e7c61cb27
出典メモuspto-grants-2015_09