HCID 178525085, compound → HCID 178525796, compound

HRID 2274781Notes

Reaction equation

HRID 2274781 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:20]3[CH:21]=[N:22][N:23]([C@H:25]4[CH2:28][C@H:27]([C:29]([OH:31])=[O:30])[CH2:26]4)[CH:24]=3)=[CH:7][N:8]2[S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[CH:4][CH:3]=1.FC1C=C2C(C(C3C=NN([C@@H]4C[C@H](C(OCC5C=CC=CC=5)=O)C4)C=3)=CN2S(C2C=CC=CC=2)(=O)=O)=CC=1>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:20]3[CH:21]=[N:22][N:23]([C@@H:25]4[CH2:28][C@H:27]([C:29]([OH:31])=[O:30])[CH2:26]4)[CH:24]=3)=[CH:7][N:8]2[S:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)(=[O:12])=[O:13])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 178525085HCID 178525085, compound2×HCID 178525797HCID 178525797, compound

Product 1

HCID 178525796HCID 178525796, compoundYield 88%

Procedure

Following the general method as outlined in Intermediate 35, starting from cis-benzyl 3-(4-(6-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl)-1H-pyrazol-1-yl)cyclobutanecarboxylate (Intermediate 34B; 600 mg; 1.13 mmol), 440 mg (88%) of the title compound was obtained as a yellow oil, which was used directly without further purification.

Sources & evidence

ORD record
ord-85683ecc9b3e4f8788088019976eb48b
Source dataset
uspto-grants-2015_09
Patent number
US09126984B2

Reaction notes

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