HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-fluoro-1-(phenylsulfonyl)-3-(1H-pyrazol-4-yl)-1H-indole → 1-(phenylsulfonyl)-3-(1H-pyrazol-4-yl)-6-(trifluoromethyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-fluoro-1-(phenylsulfonyl)-3-(1H-pyrazol-4-yl)-1H-indole | HCID 118060134 | — |
| Reactant | tert-butyl 4-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-3-yl)-1H-pyrazole-1-carboxylate | HCID 118060358 | — |
| Product | 1-(phenylsulfonyl)-3-(1H-pyrazol-4-yl)-6-(trifluoromethyl)-1H-indole | HCID 118060246 | 95% |
Reaction Steps
Following the general method as outlined in Intermediate 5, starting from tert-butyl 4-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-3-yl)-1H-pyrazole-1-carboxylate (Intermediate 41; 400 mg; 0.81 mmol), 300 mg (95%) of the title compound was obtained as a yellow oil, which was used directly without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126984B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-7ae5160ab78c41538090d4a55c3bd713 |
| Source note | uspto-grants-2015_09 |