HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxan-4-ylmethyl methanesulfonate → 6-fluoro-1-(phenylsulfonyl)-3-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazol-4-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxan-4-ylmethyl methanesulfonate | HCID 15166436 | — |
| Reactant | 5,6-difluoro-3-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)-1H-indole | HCID 118060292 | — |
| Reactant | tert-butyl 4-((4-(6-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate | HCID 118060320 | — |
| Product | 6-fluoro-1-(phenylsulfonyl)-3-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazol-4-yl)-1H-indole | HCID 118060243 | — |
Reaction Steps
Following the general method as outlined in Intermediate 20, starting from 6-fluoro-1-(phenylsulfonyl)-3-(1H-pyrazol-4-yl)-1H-indole (Intermediate 5; 305 mg; 0.89 mmol) and (tetrahydro-2H-pyran-4-yl)methyl methanesulfonate (226 mg; 1.16 mmol), 398 mg of the title compound was obtained as a white solid, which was used directly without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126984B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-b8bcf6d841d944afbfe909ccb18cfd87 |
| Source note | uspto-grants-2015_09 |