HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2274841Generated: October 29, 2026
Sodium Hydroxide → 3-(1-(6-chloropyridazin-3-yl)-1H-pyrazol-4-yl)-6-fluoro-1H-indole
https://huagongshe.com/reaction/2274841
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(1-(6-chloropyridazin-3-yl)-1H-pyrazol-4-yl)-6-fluoro-1-(phenylsulfonyl)-1H-indole | HCID 118060604 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(1-(6-chloropyridazin-3-yl)-1H-pyrazol-4-yl)-6-fluoro-1H-indole | HCID 118060584 | 28.7% |
Reaction Steps
A mixture of 3-(1-(6-chloropyridazin-3-yl)-1H-pyrazol-4-yl)-6-fluoro-1-(phenylsulfonyl)-1H-indole (Intermediate 44; 226 mg; 0.50 mmol) in THF (20 mL) was added NaOH (80 mg; 2.0 mmol). The reaction mixture was stirred at 75° C. for 16 hours, concentrated, and purified by preparative HPLC to afford 45 mg (28%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09126984B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-5047e86cdf1c41f2a2dd13363d4d7c92 |
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| Source note | uspto-grants-2015_09 |
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