1,4-Diazabicyclo(3.2.2)nonane → HCID 68328293, compound

HRID 2274883Notes

Reaction equation

HRID 2274883 reaction equation
[C:1](Cl)(=[O:15])[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[N:17]12[CH2:25][CH2:24][CH:21]([CH2:22][CH2:23]1)[NH:20][CH2:19][CH2:18]2>>[N:17]12[CH2:25][CH2:24][CH:21]([CH2:22][CH2:23]1)[N:20]([C:1]([O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:15])[CH2:19][CH2:18]2

Participants

3

Reactant 2

HCID 3984071,4-Diazabicyclo(3.2.2)nonaneHCID 17958489HCID 17958489, compound

Product 1

HCID 68328293HCID 68328293, compoundYield 15%

Procedure

Biphenyl-2-yl carbonochloridate (83.0 mg, 0.358 mmol) was treated with 1,4-diazabicyclo[3.2.2] nonane (113 mg, 0.896 mmol) using the same procedure reported in example 46 to afford the title compound as an off-white solid (17 mg, 15%). Purity: >99% UPLCMS (210 nm); retention time 0.75 min; (M+1) 323.

Sources & evidence

ORD record
ord-c4a1bed19504477f9da74557765f2946
Source dataset
uspto-grants-2015_09
Patent number
US09126993B2

Reaction notes

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