HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(3-chloro-indole-2-sulfonyl)-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Methoxy-6-(3-chloro-indole-2-sulfonyl)-pyridazine | HCID 12071771 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(3-chloro-indole-2-sulfonyl)-2H-pyridazin-3-one | HCID 12071772 | 102.6% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 3-methoxy-6-(3-chloro-indole-2-sulfonyl)-pyridazine (0.34 mmol, 110 mg), conc. HCl (1 mL), and dioxane (3 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. The dried residue was triturated with water (10 mL), and filtered to obtain 6-(3-chloro-indole-2-sulfonyl)-2H-pyridazin-3-one (99%, 108 mg); mp 250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849629B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-6af86c1d86e040e995334af91404ef21 |
| Source note | uspto-grants-2005_02 |