Morpholine → HCID 10086644, compound

HRID 227493Notes

Reaction equation

ClC1C=C2[C:8](=[CH:9][CH:10]=1)[N:7](S(C1C=CC=CC=1)(=O)=O)C(C(OCC)=O)=C2S(Cl)(=O)=O.Cl[S:30]([C:33]1[C:41]2[C:36](=[CH:37][CH:38]=[C:39]([O:42][CH3:43])[CH:40]=2)[N:35](S(C2C=CC=CC=2)(=O)=O)[C:34]=1[C:53]([O:55]CC)=O)(=[O:32])=[O:31].[NH:58]1CCOCC1.N1CCC1>>[N:7]1([S:30]([C:33]2[C:41]3[C:36](=[CH:37][CH:38]=[C:39]([O:42][CH3:43])[CH:40]=3)[NH:35][C:34]=2[C:53]([NH2:58])=[O:55])(=[O:31])=[O:32])[CH2:8][CH2:9][CH2:10]1

Participants

Reactant 4

HCID 8083Morpholine

HCID 10422Azetidine

HCID 22401482ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate

HCID 86601813HCID 86601813, compound

Product 1

HCID 10086644HCID 10086644, compound

Procedure

Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 3-(chlorosulfonyl)-5-methoxy-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and morpholine with azetidine, the title compound was obtained. HRMS (ES) exact mass calculated for C13H16N3O4S (M+H+): 310.0856. Found 310.0877.

Sources & evidence

ORD record: ord-ae181857ddc54746b287e47b262191ab
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07560546B2

Reaction notes

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