Nitric Acid → HCID 178487957, compound

HRID 2274958Notes

Reaction equation

HRID 2274958 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[OH:13].[N+:14]([O-])([OH:16])=[O:15]>>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([N+:14]([O-:16])=[O:15])=[C:6]2[OH:13]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 178487891HCID 178487891, compound

Product 1

HCID 178487957HCID 178487957, compoundYield 70%

Conditions

Temperature
67 °C

Procedure

Fuming HNO3 (500 mL) was cooled to 10-15° C. and the compound of Example 1 (80 g, 1 eq.) was added in portions over a period of 20 min. The reaction mixture was heated to 67° C. for 4 h. The mixture was cooled to 20° C. and added to ice (2 kg) with stirring. The yellow suspension was filtered and the product was washed with water (1500 mL). After drying, a yellow solid (70 g; 70% yield) was obtained.

Workup

  1. temperatureThe mixture was cooled to 20° C.
  2. filtrationThe yellow suspension was filtered
  3. washthe product was washed with water (1500 mL)
  4. customAfter drying
  5. customa yellow solid (70 g; 70% yield) was obtained

Sources & evidence

ORD record
ord-92034105abc14539b2f653fdf7a8bc26
Source dataset
uspto-grants-2015_09
Patent number
US09127002B2

Reaction notes

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