Phosphorus tribromide → HCID 71679889, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Example 2 (132.3 g, 1 eq.) was suspended in DMF (1200 mL) at 20° C. and PBr3 (68 mL, 1.2 eq.) was added over a period of 15 min. The mixture was stirred at 65° C. for 60 min, cooled to 20° C., poured on ice (800 g) and filtered. The product was slurried in ethanol (500 mL), filtered and dried on a rotary evaporator at 65° C., affording a yellow solid (155.8 g; 92% yield).

Provenance & Evidence