HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2274973Generated: October 25, 2026
2-Propanone, methylhydrazone → 3-((1-Methyl-2-(propan-2-ylidene)hydrazinyl)methylene)pentane-2,4-dione
https://huagongshe.com/reaction/2274973
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Propanone, methylhydrazone | HCID 79840 | — |
| Reactant | 3-(Ethoxymethylene)pentane-2,4-dione | HCID 240418 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-((1-Methyl-2-(propan-2-ylidene)hydrazinyl)methylene)pentane-2,4-dione | HCID 23635272 | — |
Reaction Steps
3-(ethoxymethylene)pentane-2,4-dione (Preparation 2, 8.6 g) was dissolved in Ether (30 mL) and cooled to 0° C. The reaction solution was then slowly treated with 1-methyl-2-(propan-2-ylidene)hydrazine (Preparation 1, 4.8 g) dropwise over 5 minutes, and then warmed and stirred at room temperature overnight. The reaction solution was purified directly by flash column chromatography (Biotage Quad 25; Eluent: 20% EtOH in EtOAc) to afford the title compound as a light red solid. (9.1 g, 84.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09126999B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-dd42a8b98f1940ffbbe97bea0aee796b |
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| Source note | uspto-grants-2015_09 |
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