Cesium fluoride → HCID 68444896, compound

Participants

Reaction Conditions

Reaction Steps

1-tert-Butyl-2-ethyl 5-iodo-3-(morpholin-4-ylsulfonyl)-1H-indole-1,2-dicarboxylate (54 mg, 0.096 mmol, 1.0 equiv), 1-benzofuran-2-ylboronic acid (22 mg, 0.13 mmol, 1.4 equiv), tri-t-butylphosphine (3.9 mg, 0.02 mmol, 0.2 equiv) and palladium(II)acetate (2.1 mg, 0.01 mmol, 0.1 equiv) and cesium fluoride (73 mg, 0.48 mmol, 5.0 equiv) were dissolved in 5 mL of dry DME and heated to 90° C. for 3 hours. The mixture was cooled to ambient temperature, poured into aqueous saturated NaHCO3 and the aqueous layer was extracted 3 times with ethyl acetate. The combined organic extracts were dried (Na2SO4), filtered and concentrated in vacuo to provide the titled compound. ESI+MS: 455.1 [M+H]+.

Provenance & Evidence