HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 3-[(3-Hydroxyazetidin-1-yl)sulfonyl]-5-iodo-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 3-Hydroxyazetidine | HCID 1514290 | — |
| Reactant | ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 22401482 | — |
| Reactant | ethyl 5-iodo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86601816 | — |
| Product | 3-[(3-Hydroxyazetidin-1-yl)sulfonyl]-5-iodo-1H-indole-2-carboxamide | HCID 57756209 | — |
Reaction Steps
Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-iodo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and morpholine with 3-hydroxyazetidine, the title compound was obtained. Proton NMR for the product was consistent with the titled compound. ESI+MS: 421.88 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560546B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-3a59ebb2ccbb48f7b0368248cc361783 |
| Source note | uspto-grants-2009_07 |