4-(Methylamino)-3-nitrobenzoic acid → tert-Butyl(1(4-(methylamino)-3-nitrobenzoyl)piperidin-3-yl)carbamate

HRID 2275005Notes

Reaction equation

HRID 2275005 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:2]1.[CH3:15][NH:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](O)=[O:22])=[CH:19][C:18]=1[N+:26]([O-:28])=[O:27]>>[C:10]([O:9][C:8](=[O:14])[NH:7][CH:3]1[CH2:4][CH2:5][CH2:6][N:1]([C:21](=[O:22])[C:20]2[CH:24]=[CH:25][C:17]([NH:16][CH3:15])=[C:18]([N+:26]([O-:28])=[O:27])[CH:19]=2)[CH2:2]1)([CH3:11])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 2834754-(Methylamino)-3-nitrobenzoic acidHCID 42330413-(Boc-amino)piperidine

Product 1

HCID 118181215tert-Butyl(1(4-(methylamino)-3-nitrobenzoyl)piperidin-3-yl)carbamate

Procedure

Prepared similarly to intermediate 20 from tert-butyl piperidin-3-ylcarbamate (available from, for example, Apollo Scientific Ltd) and 4-(methylamino)-3-nitrobenzoic acid.

Sources & evidence

ORD record
ord-a130a7d0bae94988a85006f613a4b7e3
Source dataset
uspto-grants-2015_09
Patent number
US09127003B2

Reaction notes

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