HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-(phenoxymethyl)morpholine → 7-Nitro-3-{[(2S)-2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-(phenoxymethyl)morpholine | HCID 42048698 | — |
| Reactant | ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86592455 | — |
| Reactant | ethyl 3-(chlorosulfonyl)-7-nitro-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86592456 | — |
| Product | 7-Nitro-3-{[(2S)-2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxylic acid | HCID 68444511 | — |
Reaction Steps
Following the procedure described in Steps B and C of Example 2, replacing in Step B ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 3-(chlorosulfonyl)-7-nitro-1-(phenylsulfonyl)-1H-indole-2-carboxylate and replacing morpholine with (S)-2-(phenoxymethyl)morpholine from Step A of Example 23, the title compound was obtained. ESI+MS: 461.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560546B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-5362104c97c44ff2ae1429d4d3db2b6b |
| Source note | uspto-grants-2009_07 |