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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2275045Generated: November 2, 2026

Hydrochloric Acid → (R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride

https://huagongshe.com/reaction/2275045

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant[(3r)-3-Aminopiperidin-1-Yl][2-(1-Ethyl-1h-Pyrrolo[2,3-B]pyridin-2-Yl)-7-Methoxy-1-Methyl-1h-Benzimidazol-5-Yl]methanoneHCID 73052938—
SolventDichloromethaneHCID 6344—
Product(R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochlorideHCID 8634015594.8%

Reaction Steps

(R)-(3-aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone (2.365 g) was dissolved in DCM (6 ml) and HCl (2M in diethyl ether) (2.735 ml, 5.47 mmol) was added to the solution. The solvent was then removed under nitrogen and concentrated under vacuum to afford the title compound as a white solid (2.43 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09127003B2
Source datasetuspto-grants-2015_09
ORD IDord-caef22d374824461a64f308a4985b0d7
Source noteuspto-grants-2015_09