HRID2275083

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)c2cc(O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21

HCID66833861

未命名化合物

结构：CC1(C)O[C@@H](C(C)(C)O[SiH2]C(C)(C)C)[C@@H](CO)O1

HCID131733422

未命名化合物

PRODUCTS

生成物

结构：CC1(C)O[C@H](COc2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)[C@@H](C(C)(C)O[SiH2]C(C)(C)C)O1

HCID178431646

未命名化合物

PROCEDURE

实验过程

Under the same conditions as the method for synthesizing Compound A7-1, the title compound was prepared from Compound A6 and [(4R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-methanol.

WORKUP

后处理

customUnder the same conditions as the method for synthesizing Compound A7-1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cfa6185561ef4f3d8025ad31a19402ef
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09126931B2
来源说明: uspto-grants-2015_09

反应 SMILES

[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17](=[O:18])[C:16]3[C:15]4[C:10](=[CH:11][C:12]([C:19]#[N:20])=[CH:13][CH:14]=4)[NH:9][C:8]=3[C:7]([CH3:22])([CH3:21])[C:6]=2[CH:23]=1.[C:24]([SiH2:28][O:29][C:30]([CH3:41])([CH3:40])[C@@H:31]1[O:35][C:34]([CH3:37])([CH3:36])[O:33][C@@H:32]1[CH2:38]O)([CH3:27])([CH3:26])[CH3:25]>>[C:24]([SiH2:28][O:29][C:30]([CH3:40])([CH3:41])[C@H:31]1[O:35][C:34]([CH3:37])([CH3:36])[O:33][C@@H:32]1[CH2:38][O:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17](=[O:18])[C:16]3[C:15]4[C:10](=[CH:11][C:12]([C:19]#[N:20])=[CH:13][CH:14]=4)[NH:9][C:8]=3[C:7]([CH3:21])([CH3:22])[C:6]=2[CH:23]=1)([CH3:27])([CH3:25])[CH3:26]