HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2275108Generated: October 26, 2026
1-Isopropylpiperazine → 8-(4-isopropylpiperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
https://huagongshe.com/reaction/2275108
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Isopropylpiperazine | HCID 78013 | — |
| Reactant | Trifluoro-methanesulfonic acid 3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl ester | HCID 86663817 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 8-(4-isopropylpiperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | HCID 49805004 | — |
Reaction Steps
Trifluoro-methanesulfonic acid 3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl ester (Compound B1, 40 mg, 0.0921 mmol) was dissolved in NMP (1 ml) and added with 1-isopropylpiperazine (236 mg, 20 eq.). The mixture was stirred at 120° C. for 3 hr. After cooling to room temperature, purification was carried out by HPLC to obtain the target compound (white powder, 12.8 mg, 34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09126931B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-162911b1984e44379174ba8c482f3cd1 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
