HCID 68442892, compound → HCID 57756195, compound

HRID 227513Notes

Reaction equation

HRID 227513 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-])=O)[NH:7][C:6]([C:14](OCC)=[O:15])=[C:5]2[S:19]([N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1)(=[O:21])=[O:20].BrC1C([N+]([O-])=O)=C2C(=CC=1)[NH:34]C(C(OCC)=O)=C2S(N1CCOCC1)(=O)=O>>[Br:1][C:2]1[C:10]([NH2:11])=[C:9]2[C:8](=[CH:4][CH:3]=1)[NH:7][C:6]([C:14]([NH2:34])=[O:15])=[C:5]2[S:19]([N:22]1[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1)(=[O:21])=[O:20]

Participants

3

Reactant 2

HCID 68442892HCID 68442892, compoundHCID 68443004HCID 68443004, compound

Product 1

HCID 57756195HCID 57756195, compound

Procedure

Using the procedures described in Example 47, replacing in Step A ethyl 5-bromo-6-nitro-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-bromo-4-nitro-3-(morpholin-4-ylsulfonyl)-1H-indole-2-carboxylate, the title compound was obtained. Proton NMR for the product was consistent with the titled compound. ESI+MS: 403.2 [M+H]+.

Sources & evidence

ORD record
ord-74ef46a01e8048009a8b0952760a4175
Source dataset
uspto-grants-2009_07
Patent number
US07560546B2

Reaction notes

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