反应详情

8-(2-Diethylamino-ethylsulfanyl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile (Compound B2-17, 16.8 mg, 0.0402 mmol) was dissolved in methanol (1.5 mL), added with oxone (54.3 mg, 2.2 eq.) which had been dissolved in water (0.5 mL), and then stirred at room temperature for 2 hr. The reaction solution was concentrated, extracted with ethyl acetate, washed with saturated sodium hydrogen carbonate, and dried over magnesium sulfate. The drying agent was removed by filtration and the residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (dichloromethane/methanol) to obtain the target compound (white solid, 5.8 mg, 32%).

1. concentrationThe reaction solution was concentrated
2. extractionextracted with ethyl acetate
3. washwashed with saturated sodium hydrogen carbonate
4. dry with materialdried over magnesium sulfate
5. customThe drying agent was removed by filtration
6. customthe residues obtained
7. concentrationafter concentration under reduced pressure
8. customwere purified by silica gel column chromatography (dichloromethane/methanol)
9. customto obtain the target compound (white solid, 5.8 mg, 32%)