反应详情

To a solution of 5-chloro-3-methyl benzofuran-2-carboxaldehyde (5.55 mmol, 1.08 g) in ethanol (25 mL) was added portion-wise sodium borohydride (16.6 mmol, 630 mg). After one hour, the ethanol was evaporated and the residue was partitioned between CHCl3 and H2O. The CHCl3 layer was collected, filtered, dried, and evaporated to dryness to obtain 5-chloro-3-methyl benzofuran 2-methanol (88%, 965 mg); mp 112° C.-113° C.

1. customthe ethanol was evaporated
2. customthe residue was partitioned between CHCl3 and H2O
3. customThe CHCl3 layer was collected
4. filtrationfiltered
5. customdried
6. customevaporated to dryness