HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-fluoro-1H-benzimidazole-2-thiol → 2-[4-[2-(5-fluorobenzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(2,2,2-trifluoroethoxy)-6-methylpyridin-3-yl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-fluoro-1H-benzimidazole-2-thiol | HCID 3434885 | — |
| Reactant | 2-[4-(2-hydroxyethyl)piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide | HCID 11689240 | — |
| Reactant | 2-[4-(2-hydroxyethyl)piperazin-1-yl]-N-[2,4 bis(2,2,2-trifluoroethoxy)-6-methylpyridin-3-yl]acetamide | HCID 23110955 | — |
| Reactant | HCID 178527775 | HCID 178527775 | — |
| Product | 2-[4-[2-(5-fluorobenzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(2,2,2-trifluoroethoxy)-6-methylpyridin-3-yl]acetamide | HCID 23116159 | — |
Reaction Steps
The reaction and treatments of Example 12 were repeated, except that 2-[4-(2-hydroxyethyl)piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methylpyridin-3-yl]acetamide was replaced by 2-[4-(2-hydroxyethyl) piperazin-1-yl]-N-[2, 4-bis(2,2,2-trifluoroethoxy)-6-methylpyridin-3-yl]acetamide, and 2-mercaptobenzimidazole was replaced by 5-fluoro-2-mercaptobenzimidazole, to thereby yield the title compound as a pale brown foamed substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560547B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-5745e515fa364429b404e8a4a5335569 |
| Source note | uspto-grants-2009_07 |