2-Tert-butylpropanedioic acid → 4-(6-Methoxy-pyridin-2-yl)-4-methyl-3-oxo-pentanoic acid tert-butyl ester

HRID 2275273Notes

Reaction equation

HRID 2275273 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=O)[CH:6]=[CH:5][CH:4]=1.C([CH:19]([C:23]([OH:25])=[O:24])C(O)=O)(C)(C)C>>[C:9]([O:25][C:23](=[O:24])[CH2:19][C:10](=[O:12])[C:9]([C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=1)([CH3:14])[CH3:13])([CH3:13])([CH3:10])[CH3:7]

Participants

3

Reactant 2

HCID 2427522-Tert-butylpropanedioic acidHCID 668349942-(6-Methoxypyridin-2-yl)-2-methylpropanoic acid

Product 1

HCID 668345394-(6-Methoxy-pyridin-2-yl)-4-methyl-3-oxo-pentanoic acid tert-butyl ester

Procedure

The title compound was synthesized from 2-(6-methoxy-pyridin-2-yl)-2-methyl-propionic acid and mono-tert-butyl malonic acid according to the method used for the synthesis of Compound PR4. The resultant was used for the next step without further purification.

Workup

  1. customused for the synthesis of Compound PR4
  2. customThe resultant was used for the next step without further purification

Sources & evidence

ORD record
ord-c8c729664cae41a19f9f987239398a62
Source dataset
uspto-grants-2015_09
Patent number
US09126931B2

Reaction notes

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