Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Allyl acetate | HCID 11584 | — |
| Reactant | 14-Hydroxymorphine-6-one | HCID 15286253 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Naloxone | HCID 5284596 | — |
Reaction Steps
In one embodiment, allylation of noroxymorphone with allyl acetate is accomplished by combining noroxymorphone with triethylamine (3 equivalents), toluene (50 mL) and tetrakis(triphenylphosphine)palladium[0] (0.1 equivalent), and heating the mixture at 80° C. for 64 hours. The mixture is cooled to a temperature of about 20° C. and filtered through a plug of CELITE and the filtrate was concentrated under reduced pressure. Naloxone is isolated from the concentrated filtrate using normal extractive procedures.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09127014B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-4e4aeda43d8349729d5f4759541f7733 |
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| Source note | uspto-grants-2015_09 |
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