Methyl iodide → HCID 86673014, compound

HRID 2275313Notes

Reaction equation

HRID 2275313 reaction equation
[CH3:1][C:2]1[CH:29]=[C:28]([CH3:30])[CH:27]=[CH:26][C:3]=1[C:4]([NH:6][C:7]1[C:11]2[CH2:12][CH2:13][N:14]3[C:18]([C:10]=2[NH:9][N:8]=1)=[CH:17][C:16]([C:19]([N:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1)=[O:20])=[CH:15]3)=[O:5].Cl[CH2:32]Cl.CI>O>[CH3:1][C:2]1[CH:29]=[C:28]([CH3:30])[CH:27]=[CH:26][C:3]=1[C:4]([NH:6][C:7]1[C:11]2[CH2:12][CH2:13][N:14]3[C:18]([C:10]=2[N:9]([CH3:32])[N:8]=1)=[CH:17][C:16]([C:19]([N:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1)=[O:20])=[CH:15]3)=[O:5]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 6344DichloromethaneHCID 53251760HCID 53251760, compound

Product 1

HCID 86673014HCID 86673014, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

After dissolving the compound 2,4-dimethyl-N-[8-(pyrrolidin-1-ylcarbonyl)-4,5-dihydro-1H-pyrazolo[4,3-g]indolizin-3-yl]benzamide (A35-M1-B8, Entry 200, Table III), obtained as described in the example 9, in dichloromethane 2 equivalent of methyl iodide were added. After four hours of stirring at room temperature, water was added and the phases were separated. The organic layer was Dried over Na2SO4 and the crude was purified through preparative HPLC. LCMS m/z 418 [M+H]+@ Rt2.87 min.

Workup

  1. customobtained
  2. additionwere added
  3. customthe phases were separated
  4. dry with materialThe organic layer was Dried over Na2SO4
  5. customthe crude was purified through preparative HPLC

Sources & evidence

ORD record
ord-afc8c2d602fc4eafb97f9bdc1b20c58c
Source dataset
uspto-grants-2015_09
Patent number
US09127015B2

Reaction notes

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