化工社化工社 化学情報印刷レポート · 研究参考用
Cyclohexylamine → 3-(Cyclohexylamino)-2,3-dihydro-1H-inden-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | 3-Bromo-1-indanone | HCID 11745912 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 3-(Cyclohexylamino)-2,3-dihydro-1H-inden-1-one | HCID 42614802 | 84% |
反応手順
3-Bromo-2,3-dihydro-1H-inden-1-one (100 mg, 475 μmol) and cyclohexylamine (94 mg, 951 μmol) were dissolved in 2 mL of dry benzene and stirred under N2 until precipitation ceased (˜15 min). The cyclohexylamine•HBr was removed by filtration. The filtrate was applied to a flash SiO2 column that was developed with 8:1 hexanes-EtOAc to give the title compound as a clear oil (91 mg, 84% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09127016B2 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-44ffc9d453cf48b2b7756dc3c2501105 |
| 出典メモ | uspto-grants-2015_09 |